1,25-Dihydroxyvitamin D3 Protects HL60 Cells against Apoptosis but Down-regulates the Expression of the bcl-2 Gene
โ Scribed by Hui-Min Xu; Clifford G. Tepper; Jennifer B. Jones; Cesar E. Fernandez; George P. Studzinski
- Book ID
- 115601612
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 837 KB
- Volume
- 209
- Category
- Article
- ISSN
- 0014-4827
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The vitamin D receptor (VDR) is a nuclear receptor that mediates the effect of the active metabolite of vitamin D3, the 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3). To investigate the potential role of this hormone in the peripheral nervous system, we have studied the VDR expression in Schwann cells. Th
Activation of ERK1 and ERK2 protein kinases has been implicated in diverse cellular processes, including the control of cell proliferation and cell differentiation (Marshall [1995] Cell 80:179). In human myeloblastoid leukemia HL60 cells rapid (ca. 15 min) but transient activation of ERK1/2 has been