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1,25-Dihydroxyvitamin D3 induces Ca2+-mediated apoptosis in adipocytes via activation of calpain and caspase-12

โœ Scribed by Igor N. Sergeev


Book ID
116298548
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
273 KB
Volume
384
Category
Article
ISSN
0006-291X

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The physiologically active form of vitamin D, 1a,25-dihydroxyvitamin D 3 (1,25D 3 ), induces promyelocytic HL60 cells to differentiate towards monocytelike cells. During this differentiation increased cytosolic calcium (Ca 2/ i ) and expression of surface receptors for chemotactic factors ''prime''