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1,25-dihydroxyvitamin D3 increases osteoblast-specific transgene expression regulated by human osteocalcin gene flanking sequences

✍ Scribed by Sims, N.A.; Gardiner, E.M.; White, C.P.; Drummond, M.L.; Morrison, N.A.; Eisman, J.A.

Book ID: 123383170
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 156 KB
Volume: 19
Category: Article
ISSN: 8756-3282
DOI: 10.1016/S8756-3282(96)90856-X

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Core binding factor alpha 1 (Cbfa1) is an osteoblast-specific transcription factor essential to develop a mature osteoblast phenotype. However, its exact role in the signaling of various osteotropic-differentiating agents is still unclear. In this study, we assessed the effects of 1,25-(OH)(2)-D3 (D