✦ LIBER ✦

1,25-Dihydroxyvitamin D3: A novel agent for enhancing wound healing

✍ Scribed by Xiao Q. Tian; Tai C. Chen; Dr. Michael F. Holick

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 353 KB
Volume: 59
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240590107

No coin nor oath required. For personal study only.

✦ Synopsis

1,25-Dihydroxyvitamin D 3 (1 ,25(OH)2D3), has diverse effects in a variety of tissues and cell types, including skin. Since 1 affects both fibroblast and keratinocytes, we evalauated the effect of 1 ,25(OH)2D3 on wound healing. We investigated the effect of the topically applied 1,25(OH)2D3 or vehicle on the healing of cutaneous wounds in rats in a blinded manner. Wound areas were measured by planimetry technique. Healing was expressed as the percentage of the original wound area that was healed. 1 ,25(OH)2D3 at concentrations between 5 and 50 ng/day caused a dose-dependent acceleration of healing. Time course and specificity studies indicated that 1,25(OH)2D3 specifically promoted healing between 1-5 days after wounding as compared with vitamin D (0.5 &day), which showed no significant improvement over control. Our results suggest that 1 ,25(OH)?D3 and its analogues may be a new class of compounds that could be developed to enhance wound healing.

📜 SIMILAR VOLUMES

Synthesis of 1α,25-Dihydroxyvitamin D3-2

Synthesis of 1α,25-Dihydroxyvitamin D3-26,23-Lactams (DLAMs), a Novel Series of 1α,25-Dihydroxyvitamin D3 Antagonist.

✍ Yuko Kato; Yusuke Nakano; Hiroko Sano; Aya Tanatani; Hisayoshi Kobayashi; Rumiko 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 29 KB 👁 1 views

## Abstract For Abstract see ChemInform Abstract in Full Text.

ChemInform Abstract: A Novel and Practic

ChemInform Abstract: A Novel and Practical Route to A-Ring Enyne Synthon for 1α,25-Dihydroxyvitamin D3 Analogues: Synthesis of A-Ring Diastereomers of 1α,25-Dihydroxyvitamin D3 and 2-Methyl-1,25-dihydroxyvitamin D3.

✍ K. KONNO; S. MAKI; T. FUJISHIMA; Z. LIU; D. MIURA; M. CHOKKI; H. TAKAYAMA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 46 KB 👁 2 views

Characterization of an enhancer required

Characterization of an enhancer required for 1,25-dihydroxyvitamin D3-dependent transactivation of the rat osteocalcin gene

✍ W. Bruce Sneddon; Marie B. Demay 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 96 KB

The sequences in the rat osteocalcin gene that lie 3Ј to the vitamin D response element (VDRE) contain a GGTTTGG motif (-420 to -414) that is essential for transcriptional activation of osteocalcin-CAT (OC-CAT) fusion genes by 1,25(OH) 2 D 3 . A second copy of this motif, present on the antisense st

ChemInform Abstract: A New A-Ring Precur

ChemInform Abstract: A New A-Ring Precursor for 19-Nor-1α,25-dihydroxyvitamin D3 Analogues.

✍ W. YONG; M. VANDEWALLE 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 1 views

ChemInform Abstract: A Practical Synthes

ChemInform Abstract: A Practical Synthesis of A-Ring Precursors for 19-Nor-1α,25-dihydroxyvitamin D3 Analogues.

✍ S.-Z. ZHOU; S. ANNE; M. VANDEWALLE 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

A Practical Synthesis of A-Ring Precursors for 19-Nor-1α,25dihydroxyvitamin D3 Analogues. -Starting with the chiral diepoxide (II), the target compounds (XI) and (XVII) are prepared following a convergent and more practical route.

Normal rabbit intestinal cytosol as a so

Normal rabbit intestinal cytosol as a source of binding protein for the 1,25-dihydroxyvitamin D3 assay

✍ W.E. Duncan; T.C. Aw; P.G. Walsh; J.G. Haddad 📂 Article 📅 1983 🏛 Elsevier Science 🌐 English ⚖ 460 KB

Cytosol prepared from small intestine of vitamin D-sufficient rabbits contains a specific highaffinity binding protein for 1,25dihydroxyvitamin D, (1,2S(OH),Ds). This binding protein sediments at 3.0-3.5 S in sucrose. density gradients containing 0.3 M KCI. Scatchard analysis using intestinal cytoso