1,2,4-Triazol-3-yl-thiopropyl-tetrahydrobenzazepines: A Series of Potent and Selective Dopamine D 3 Receptor Antagonists
β Scribed by Micheli, Fabrizio; Bonanomi, Giorgio; Blaney, Frank E.; Braggio, Simone; Capelli, Anna Maria; Checchia, Anna; Curcuruto, Ornella; Damiani, Federica; Di Fabio, Romano; Donati, Daniele; Gentile, Gabriella; Gribble, Andy; Hamprecht, Dieter; Tedesco, Giovanna; Terreni, Silvia; Tarsi, Luca; Lightfoot, Andrew; Stemp, Geoff; MacDonald, Gregor; Smith, Alex; Pecoraro, Michela; Petrone, Marcella; Perini, Ornella; Piner, Jacqui; Rossi, Tino; Worby, Angela; Pilla, Maria; Valerio, Enzo; Griffante, Cristiana; Mugnaini, Manolo; Wood, Martyn; Scott, Claire; Andreoli, Michela; Lacroix, Laurent; Schwarz, Adam; Gozzi, Alessandro; Bifone, Angelo; Ashby,, Charles R.; Hagan, Jim J.; Heidbreder, Christian
- Book ID
- 120435381
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 281 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-2623
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π SIMILAR VOLUMES
## Abstract __Herein we report a detailed description of the structureβactivity relationships for a novel series of βCβlinkedβ 1,2,4βtriazolylazabicyclo[3.1.0]hexanes. These derivatives are endowed with very high inβ vitro affinity and selectivity for the dopamine D~3~ receptor. An optimization with