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1,2,4-triazines. 7. Regioselective n2-amination of 3-methylthio-1,2,4-triazin-5(2H)-ones.A novel synthesis of [1,2,4]triazolo[2,3-b][1,2,4]triazinones and -triazine

โœ Scribed by Yuzuru Sanemitsu; Yoshinori Nakayama; Masao Shiroshita


Book ID
112127300
Publisher
Journal of Heterocyclic Chemistry
Year
1983
Tongue
English
Weight
322 KB
Volume
20
Category
Article
ISSN
0022-152X

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To develop nonacidic, nonsteroidal anti-inflammatory agents without GI complications, a series of asymmetric triazines was synthesized and evaluated for anti-inflammatory efficacy in the carrageenan-induced pedal edema assay. Toxicity was estimated by determination of approximate LD50 values in mice