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[123I]FP-CIT SPET imaging in drug-induced Parkinsonism

✍ Scribed by Michele Tinazzi; Sarah Ottaviani; Ioannis U. Isaias; Isabella Pasquin; Maria Steinmayr; Claudio Vampini; Manuela Pilleri; Giuseppe Moretto; Antonio Fiaschi; Nicola Smania; Piergiorgio Giorgetti; Angelo Antonini

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
88 KB
Volume
23
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We assessed the status of dopamine nerve terminals in patients treated with dopamine receptor blocking agents (DRBAs) who had developed drug‐induced parkinsonism (DIP). We performed [^123^I]FP‐CIT SPET in 32 consecutive patients who were on DRBAs for at least 6 months and developed extrapyramidal signs. The UPDRS‐III was used to assess clinical severity. Twenty‐six age‐ and sex‐matched healthy subjects served as control group. Putamen [^123^I]FP‐CIT SPET binding was reduced in 14 and normal in the remaining 18 patients. There was no difference between the two groups for age, duration of DRBAs treatment, UPDRS III, tremor, rigidity, and bradykinesia subscores for upper and lower limbs. Conversely, symmetry of parkinsonian signs and presence bucco‐linguo‐masticatory dyskinesias were more frequent in individuals with normal tracer binding. Imaging of the dopamine transporter may help to identify subjects with DIP secondary to a loss of dopamine nerve terminals. © 2008 Movement Disorder Society

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In the above-mentioned article, several errors were made in referencing LSVT 1 BIG and LSVT 1 LOUD. The corrected article can be found as supporting information at wileyonlinelibrary.com The publisher regrets this error.