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123 Activity of N4-Octadecyl-Ara-C in human solid tumor xenografts and leukemias

✍ Scribed by H.H. Fiebig; W.A. Dengler; M. Drees; T. Ruhnau


Book ID
116166881
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
163 KB
Volume
31
Category
Article
ISSN
0959-8049

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## Abstract The contribution of P‐glycoprotein (Pgp) to multidrug resistance in human solid tumors is generally estimated from bulk mRNA measurements or immunohistochemistry, while direct measurement of the effect of Pgp on intracellular drug concentrations has not been pursued. We investigated the