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1.202 Time estimation in patients with Parkinson's disease and Friedreich's ataxia

โœ Scribed by M. Beudel; S. Galama; K.L. Leenders; B.M. de Jong


Book ID
117752716
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
71 KB
Volume
13
Category
Article
ISSN
1353-8020

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Friedreich's ataxia (FRDA) is caused by point mutations or trinucleotide repeat expansions in both alleles of the gene encoding frataxin. Studies of frataxin homologues in lower eukaryotes suggest that mitochondrial iron accumulation may underlie the pathophysiology of FRDA. To evaluate the possible