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12-O-tetradecanoylphorbol-13-acetate (TPA) Inhibits Osteoclastogenesis by Suppressing RANKL-Induced NF-κB Activation

✍ Scribed by Cathy Wang; James H Steer; David A Joyce; Kirk HM Yip; Ming H Zheng; Jiake XU

Book ID: 111487241
Publisher: American Society for Bone and Mineral Research
Year: 2003
Tongue: English
Weight: 530 KB
Volume: 18
Category: Article
ISSN: 0884-0431
DOI: 10.1359/jbmr.2003.18.12.2159

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## Abstract An increase in __MMP‐9__ gene expression and enzyme activity with stimulating the migration of GBM8401 glioma cells via wound healing assay by 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA) was detected in glioblastoma cells GBM8401. TPA‐induced translocation of protein kinase C (PKC)α