1,2-Diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties
β Scribed by Alec D. Lebsack; Jason C. Rech; Bryan J. Branstetter; Natalie A. Hawryluk; Jeffrey E. Merit; Brett Allison; Raymond Rynberg; Johnathan Buma; Michele Rizzolio; Nadia Swanson; Hong Ao; Michael P. Maher; Michelle Herrmann; Jamie Freedman; Brian P. Scott; Lin Luo; Anindya Bhattacharya; Qi Wang; Sandra R. Chaplan; Alan D. Wickenden; J. Guy Breitenbucher
- Book ID
- 104004867
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 714 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0960-894X
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## Abstract A new access to 5βphenylβ5,6,7,8βtetrahydroβ1,6βnaphthyridines **25aβ28a** (n=1) and 5βphenylβ6,7,8,9βtetrahydroβ5__H__βpyrido[3,2β__c__]azepines **25bβ28b** (n=2) has been developed by first preparing the functional pyridine moiety followed by intramolecular cyclization forming the par