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12 Approach to a sarcoma-associated chromosomal translocation: Breakpoint cloning in the absence of a candidate gene

โœ Scribed by Beverly S. Emanuel; Marcia Budart; Healther McDermid; Jaclyn Biegel


Book ID
119105437
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
99 KB
Volume
59
Category
Article
ISSN
0165-4608

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## Abstract Germโ€line mutations in the serineโ€threonine kinase gene __STK11__ (__LKB1__) cause Peutzโ€“Jeghers syndrome (PJS), a rare autosomal dominantly inherited disease, characterized by hamartomatous polyposis and mucocutaneous pigmentation. __STK11__ mutations only account for about half of PJS