Alterations in the gene copy numbers of the proto-oncogenes HERZ/neu and c-myc in primary human breast cancer investigated in 73 patients. We detected amplification of H€R2/ neu in 17 patient samples and amplification of c-myc in I I, while amplification of both was seen in 6 samples. There was no c
11q13 Amplification in local recurrence of human primary breast cancer
✍ Scribed by Marie-Hélène Champème; Ivan Bièche; Sarab Lizard; Rosette Lidereau
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 465 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1045-2257
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Amplification of sequences derived from 12q I 3-1 5 is frequent in human sarcomas and brain tumors. Detailed mapping studies of the amplified region are necessary for definition of the impact of these amplification events on the tumor cell phenotype. By using the genes in this region and genomic fra
Breast-carcinoma development presumably results from multiple mutational events in tumor-associated genes. Certain results indicate that some tumor-suppressor genes may combine their pathogenetic potential to synergistically promote tumor growth. In an effort to identify such mechanisms in breast tu