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[119] TARGETED DISRUPTION OF THE HEPATIC TRANSFERRIN RECEPTOR 2 GENE IN MICE LEADS TO IRON OVERLOAD

✍ Scribed by D.F. Wallace; L. Summerville; V.N. Subramaniam


Book ID
117375221
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
149 KB
Volume
46
Category
Article
ISSN
0168-8278

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Combined deletion of Hfe and transferrin
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Hepcidin is a central regulator of iron homeostasis. HFE and transferrin receptor 2 (TFR2) are mutated in adult-onset forms of hereditary hemochromatosis and regulate the expression of hepcidin in response to iron. Whether they act through the same or parallel pathways is unclear. To investigate thi