Combined deletion of Hfe and transferrin
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Daniel F. Wallace; Lesa Summerville; Emily M. Crampton; David M. Frazer; Gregory
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Article
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2009
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John Wiley and Sons
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English
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Hepcidin is a central regulator of iron homeostasis. HFE and transferrin receptor 2 (TFR2) are mutated in adult-onset forms of hereditary hemochromatosis and regulate the expression of hepcidin in response to iron. Whether they act through the same or parallel pathways is unclear. To investigate thi