118. Products of endogenous ADP-ribosylation in bipolar disorder (BD) postmortem brain

Altered CTX-catalyzed and endogenous [32

Altered CTX-catalyzed and endogenous [32P]ADP-ribosylation of stimulatory G protein αs isoforms in postmortem bipolar affective disorder temporal cortex

✍ Stavroula Andreopoulos; Peter P. Li; Kin Po Siu; Stephen J. Kish; Jerry J. Warsh 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB

## Abstract Reports of elevated Gs α subunit (α~s~) immunolabeling and cAMP‐mediated hyper‐functionality in autopsied cerebral cortical brain regions from bipolar affective disorder (BD) patients suggest signal transduction abnormalities occur in this disorder. Because covalent modification of α~s~