1165 IL-28B GENE POLYMORPHISM INFLUENCES HISTOLOGICAL AND BIOCHEMICAL SEVERITY OF GRAFT HEPATITIS AFTER LIVER TRANSPLANTATION FOR HCV-INDUCED LIVER DISEASE

Relationship between the interleukin-28b

Relationship between the interleukin-28b gene polymorphism and the histological severity of hepatitis C virus–induced graft inflammation and the response to antiviral therapy after liver transplantation

✍ Dennis Eurich; Sabine Boas-Knoop; Martin Ruehl; Maria Schulz; Esperanza D. Carri 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 293 KB

Up to 30% of liver transplants will develop graft cirrhosis within 5 years after liver transplantation (LT) due to recurrent HCV-infection forwarding accelerated graft damage. Genetic variants of cytokines involved in the immune response may contribute to the degree of graft inflammation, fibrosis p