## Abstract Serial monotherapy and add‐on regimes for treatment of chronic hepatitis B virus (HBV) infection may induce the accumulation of viral resistance mutations in patients, reducing the options for ongoing viral suppression. The induction of antiviral resistance by serial application of poly
1164 susceptibility of wild-type and lamivudine-resistant hepatitis B virus to tenofovir and adefovir
✍ Scribed by LADA, O; BENHAMOU, Y; VALANTIN, M; KATLAMA, C; POYNARD, T; CAHOUR, A; THIBAULT, V
- Book ID
- 123167156
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 144 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0270-9139
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Adefovir dipivoxil was recently approved for the treatment of wild-type and lamivudineresistant hepatitis B virus (HBV) infection. Tenofovir disoproxil fumarate, a congender of adefovir that is used in the treatment of HIV infected patients, has recently been shown to also be effective in patients w
## Abstract Adefovir dipivoxil has been used alone or together with lamivudine to suppress lamivudine‐resistant hepatitis B virus (HBV). However, the dynamics of HBV populations under different selection pressures and their impact on treatment outcome are poorly understood. Pyrosequencing® was appl