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1154 ROLE OF PROTEIN TYROSINE-PHOSPHATASE 1B (PTP1B) ACTIVITY IN HCV-INDUCED HEPATOCELLULAR CARCINOMA: AN IN VITRO ANALYSIS

✍ Scribed by García-Valdecasas Merino, M.; Rojas, Á.; Romero-Gomez, M.; del Campo, J.A.


Book ID
121925703
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
64 KB
Volume
58
Category
Article
ISSN
0168-8278

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## Abstract __SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a__ K__~i~ of less than 600 pM. This slow‐binding, high‐affin