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113 β1-integrin or integrin-linked kinase overexpression promotes radiation-induced apoptosis in human HL60 leukemia cells

✍ Scribed by F. Hess; D. Estrugo; A. Fischer; N. Cordes

Book ID: 119517644
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 134 KB
Volume: 78
Category: Article
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(06)80592-x

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## Abstract The human myeloid HL‐60 cell line and its cell variant HL‐525 were used to study signaling events leading to apoptosis induction by phorbol 12‐myristate 13‐acetate (PMA), an activator of protein kinase C (PKC) enzymes. Unlike parental cells, HL‐525 cells are PKC‐β deficient and resistan