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1118. Elimination–addition. Part IV. Additions of sulphur nucleophiles to allenic and acetylenic sulphones

✍ Scribed by Stirling, C. J. M.


Book ID
118119892
Publisher
The Royal Society of Chemistry
Year
1964
Weight
722 KB
Volume
0
Category
Article
ISSN
0368-1769

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We have discovered that chlorine in 3~-acetoxy-17-chloro-16-formylandrosta-5,16-diene (1) can be smoothly displaced by nitrogen heterocyclic nucleophiles (her) to give heretofore unknown 17-substituted-A t6 steroids in high yields (73-92%). This enabled us to synthesize novel 3~-hydroxy-17-(1H-1,2,4