1,1,1,3,3,3-Hexafluoro-2-propanol for the removal of the 4,4′-DimethoxytrityI protecting group from the 5′-hydroxyl of acid-sensitive nucleosides and nucleotides
✍ Scribed by Nelson J. Leonard; Neelima
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 211 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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## Abstract magnified image We describe basic chemical properties of 4,5‐di(ethoxycarbonyl)‐1,3‐dioxolan‐2‐yl (DECDO) in view of its use as a protecting group for the 2′‐hydroxyl function of ribonucleosides. The DECDO group is found to be compatible with the DMTr strategy for the currently‐used ol
## Abstract Facile, alternative synthetic routes to **6**, **(R)‐6**, and **(S)‐6**‐3‐benzyl‐__N__‐(2,6‐dimethylphenyl)‐1,3‐oxazolidine‐4‐carboxamides (**6**), a chiral oxazolidine derivative of tocainide, are reported. The synthetic routes described herein also afforded **11**‐, **(R)‐11**‐, and *