## Abstract Mitochondrial DNA (mtDNA) of peripheral blood mononuclear cells (PBMCs) collected from Human immunodeficiency virus 1 (HIV‐1)‐infected patients and healthy controls were measured longitudinally using real‐time polymerase chain reaction to evaluate the effects of antiretroviral agents on
11 HIV and antiretroviral-mediated mitochondrial dna depletion in children
✍ Scribed by Constanza Morén; Núria Rovira; Antoni Noguera; Glòria Garrabou; Mireia Nicolàs; Francesc Cardellach; Òscar Miró; Clàudia Fortuny
- Book ID
- 116751925
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 42 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1567-7249
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## Abstract The nucleoside reverse transcriptase inhibitors (NRTIs), especially stavudine, may deplete mitochondrial (mt) DNA in human tissues by inhibiting the mitochondrial polymerase gamma, a setting, which is associated with hyperlactatemia. The aim of the present study was to examine whether h
The "D drug" HIV reverse-transcriptase inhibitors zalcitabine, didanosine, and stavudine are relatively strong inhibitors of polymerase-gamma compared with the "non-D drugs" zidovudine, lamivudine, and abacavir. D drugs deplete mitochondrial DNA (mtDNA) in cultured hepatocytes. This mtDNA depletion