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1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) disrupts the estrogen-androgen balance regulating the growth of hormone-dependent breast cancer cells

✍ Scribed by Michel Aubé, Christian Larochelle, Pierre Ayotte

Book ID: 120699253
Publisher: BioMed Central
Year: 2008
Tongue: English
Weight: 998 KB
Volume: 10
Category: Article
ISSN: 1465-5411
DOI: 10.1186/bcr1862

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## Abstract Expression of an estrogen receptor α (ER) transgene in hormone independent breast cancer and normal breast epithelial cells arrests cell cycling when estradiol is added. Although endogenously expressed ER does not typically affect estradiol‐induced cell cycling of hormone dependent brea