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1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPAR -dependent and PPAR -independent pathways

✍ Scribed by Chintharlapalli, S.

Book ID: 119941853
Publisher: American Association for Cancer Research
Year: 2006
Tongue: English
Weight: 471 KB
Volume: 5
Category: Article
ISSN: 1535-7163
DOI: 10.1158/1535-7163.MCT-06-0002

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## Abstract 1,1‐Bis(3′‐indolyl)‐1‐(__p__‐substituted phenyl)methanes, containing __p‐t‐__butyl (DIM‐C‐pPhtBu) and phenyl (DIM‐C‐pPhC~6~H~5~) substituents, are peroxisome proliferator‐activated receptor γ (PPARγ) agonists; however, DIM‐C‐pPhtBu‐induced growth inhibition and cell death in human HEC1A