11. Antisense oligonucleotides in the treatment after auto – PBSCT of three children with hematological malignancies
✍ Scribed by A. Chybicka; R. Chaber; J. Toporski; M. Ussowicz
- Publisher
- Wielkopolskie Centrum Onkologii
- Year
- 2001
- Tongue
- Polish
- Weight
- 98 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1507-1367
No coin nor oath required. For personal study only.
✦ Synopsis
sister (20 x 10 6 CD34 cells/kg). As acute graft versus host disease prophylaxis she received cyclosporin A (1,5 mg/kg from day -1). From day +16 we observed aGVHD ,,0 in the skin and gastrointestinal tract. Administration of metylprednisolon in max. dose of 1,5 mg/kg proved effecttive. No toxicity attributable to the conditioning regimen was noted. She was discharged on day +36.
Complete donor chimerism was reached by day + 14 and has not changed since then. On day + 183 the girl is doing well with stable haematopoiesis of donor origin.
We conclude that preparative regimen containing treosulfan is a reasonable option in heavily treated children undergoing bone marrow transplantation.