10aS)-7-Methoxy-1,10a-dihydropyrrolo[1,2-b]isoquinoline-3,10(2H,5H)-dione Viktor Vra ´bel, a \* Jozef Koz ˇı ´s ˇek, b S ˘tefan Marchalı ´nc and Katarı ´na Kadlec ˇı ´kova ´c a
(10aS)-6-Methoxy-1,10a-dihydropyrrolo[1,2-b]isoquinoline-3,10(2H,5H)-dione
✍ Scribed by Švorc, Ľubomír ;Vrábel, Viktor ;Kožíšek, Jozef ;Marchalín, Štefan ;Žúžiová, Jozefína
- Publisher
- International Union of Crystallography
- Year
- 2007
- Tongue
- English
- Weight
- 788 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1600-5368
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A new synthesis of imidazo[1,5-b]isoquinolines is reported. 2-[2-(Piperidino)ethyl]-10,10a-dihydro-1H,5H-imidazo[1,5-b]isoquinoline-1,3(2H)-dione hydrochloride was found to posses anti-inflammatory activity.
Single-crystal X-ray study T = 293 K Mean '(C±C) = 0.003 A Ê R factor = 0.045 wR factor = 0.135 Data-to-parameter ratio = 14.3 For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract On treatment with lead tetraacetate (Pb(OAc)~4~), the 1‐(alkylidene)‐1,2,3,4‐tetrahydro‐__N__‐(trichloroacetyl)isoquinolines **2a**–**2c** as well as the tribromoacetyl derivative **4** undergo an oxidative cyclization with concomitant migration of the trihalogenomethyl group to afford