108. PML: a new zinc finger protein involved in the t(15;17) translocation of acute promyelocytic leukemia
✍ Scribed by de Thé, H; Lavau, C; Chomienne, C; Marchio, A; Degos, L; Dejean, A
- Book ID
- 122405027
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 67 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0753-3322
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## Abstract The genomic breakpoints in the t(15;17)(q22;q21), associated with acute promyelocytic leukemia (APL), are known to occur within three different __PML__ breakpoint cluster regions (bcr) on chromosome 15 and within __RARA__ intron 2 on chromosome 17; however, the precise mechanism by whic
A reciprocal chromosomal translocation, t( I 5; I7)(q22;q I I .2-I2), is characteristic of acute promyelocytic leukemia (APL) of French-American-British (FAB) subtype M3, and is not associated with any other human malignancy. The non-random pattern of the APL translocations suggests that specific ge