✦ LIBER ✦

108 Discovery of CH5132799, a novel class I PI3K inhibitor

✍ Scribed by J. Ohwada; H. Ebiike; H. Kawada; M. Tsukazaki; M. Nakamura; K. Morikami; K. Morita; M. Yoshida; O. Kondoh; N. Shimma

Book ID: 119602790
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 60 KB
Volume: 8
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(10)71813-9

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

122 Novel class I PI3K inhibitor CH51327

122 Novel class I PI3K inhibitor CH5132799: potential clinical application in rational combination with molecular targeted therapeutics

✍ H. Tanaka; M. Yoshida; H. Tanimura; T. Yamazaki; J. Ohwada; H. Ebiike; Y. Yoshim 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 45 KB

74 Novel class I PI3K inhibitor CH513279

74 Novel class I PI3K inhibitor CH5132799: disruption of the activated PI3K signaling in PIK3CA mutants confers potent antitumor efficacy

✍ M. Yoshida; H. Tanaka; H. Tanimura; T. Fujii; K. Sakata; J. Ohwada; Y. Yoshimura 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 44 KB

Discovery of novel class 1 phosphatidyli

Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening

✍ Fabrizio Giordanetto; Bengt Kull; Anita Dellsén 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 1002 KB

The discovery of ligand efficient and lipophilicity efficient fragment inhibitors of class 1 phosphatidylinositide 3-kinases (PI3K) is reported. A fragment version of the AstraZeneca compound bank was docked to a homology model of the PI3K p110β isoform. Interaction-based scoring of the predicted bi

Fragment based discovery of a novel and

Fragment based discovery of a novel and selective PI3 kinase inhibitor

✍ Samantha J. Hughes; David S. Millan; Iain C. Kilty; Russell A. Lewthwaite; John 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 658 KB

Discovery of novel morpholino–quinoxalin

Discovery of novel morpholino–quinoxalines as PI3Kα inhibitors by pharmacophore-based screening

✍ Wu, Peng; Su, Yi; Liu, Xiaowen; Yan, Jingying; Ye, Yong; Zhang, Lei; Xu, Jiancha 📂 Article 📅 2012 🏛 The Royal Society of Chemistry 🌐 English ⚖ 349 KB

Discovery of novel 2-piperidinol-3-(aryl

Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors

✍ Peng Wu; Yi Su; Xiaowen Liu; Bo Yang; Qiaojun He; Yongzhou Hu 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 1005 KB