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107 INVITED Hypoxia inducible factor-1 as a novel target for cancer drug development


Book ID
118622694
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
127 KB
Volume
3
Category
Article
ISSN
1359-6349

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Growing evidence has demonstrated that clonogenic cancer stem (initiating) cells are responsible for tumor regrowth and disease relapse. Bmi-1 plays a critical role in the self-renewal of adult stem cells. The Bmi-1 protein is elevated in many types of cancers, and experimental reduction of Bmi-1 pr