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1051 THE MAGNITUDE OF THE RESPONSE OF HEPATOCELLULAR CARCINOMA AND CHOLANGIOCARCINOMA TO SORAFENIB IS AFFECTED BY THE EXPRESSION OF INACTIVATING VARIANTS IN THE SLC22A1 GENE

✍ Scribed by Herráez, E.; Briz, O.; Lozano, E.; Macias, R.I.R.; Robledo, V.S.; Hernandez-Iglesias, J.; González-Hernandez, A.; Bujanda, L.; Banales, J.; Marin, J.J.G.


Book ID
123078833
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
81 KB
Volume
58
Category
Article
ISSN
0168-8278

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## Abstract O^6^‐methylguanine‐DNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylation‐specific PCR (MSP)