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1051 Knockdown of LINE-1 Enhances Sensitivity to 5-FU in LINE-1-hypomethylated Colorectal Cancer Cell

โœ Scribed by K. Kawakami; A. Matsunoki; M. Kotake; M. Kaneko; H. Kitamura; G. Watanabe; T. Minamoto

Book ID
117663494
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
76 KB
Volume
48
Category
Article
ISSN
0959-8049

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## Abstract Loss of DNA mismatch repair (MMR) occurs in 10โ€“15% of sporadic colorectal cancer, is usually caused by hMLH1 hypermethylation, and has been shown to confer resistance to various chemotherapeutic reagents, including 5โ€fluorouracil (5โ€FU). We tested the hypothesis that demethylation of th