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1016 Prognostic and predictive significance of BRAF mutation in patients with metastatic colorectal cancer treated with 5-fluorouracil-based 1st line chemotherapy

✍ Scribed by Z. Saridaki; M. Tzardi; D. Papadatos-Patsos; E. Kampouraki; E. Zois; E. Stathopoulos; V. Georgoulias; D. Mavroudis; J. Souglakos

Book ID
119600070
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
67 KB
Volume
7
Category
Article
ISSN
1359-6349

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## Abstract Cytotoxic effect of 5‐fluorouracil 5‐FU is mediated through inhibition of thymidylate synthase (TS), and 5‐FU is catabolised by dihydropyrimidine dehydrogenase (DPD). Efficacy of 5‐FU may therefore depend on the TS and DPD activity of colorectal cancer. Archival tumour specimens from 30