1-vinylbenzene 1,2- and 3,4-oxides

✍ Scribed by Tadashi Watabe; Akira Hiratsuka; Toshiko Aizawa; Tadashi Sawahata

• Book ID: 104220554
• Publisher: Elsevier Science
• Year: 1982
• Tongue: French
• Weight: 310 KB
• Volume: 23
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)87055-0

✦ Synopsis

Synthesis of highly unstable vinyl-substituted benzene oxides has been established. The recent demonstration that phenyloxirane as the major metabolite of styrene in liver microsomes plays a minor role in the styrene-induced reverse mutation of bacteria' raised a question whether 1-vinylbenzene 3,4-oxide, a putative precursor of previously isolated 4-vinylphenol as the urinary metabolite of the plastic monomer,2 was an ultimate mutagen. However, little predictable information is available as yet on the synthesis and the nature of the vinylsubstituted benzene oxide despite of recent fruitful works on the synthesis of highly reactive