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1-Methyl-4-phenylpyridinium (MPP+) analogs: in vivo neurotoxicity and inhibition of striatal synaptosomal dopamine uptake

✍ Scribed by E.Anne Johnson; Ellen Y. Wu; Hans Rollema; Raymond G. Booth; Anthony J. Trevor; Neal Castagnoli Jr.


Book ID
115882705
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
724 KB
Volume
166
Category
Article
ISSN
0014-2999

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We have studied the effect of a semichronic and acute treatment of phenobarbital on in vivo 1-methyl-4-phenylpyridinium ion- (MPP+)-induced neurotoxicity. A group of rats were intraperitoneally injected for 12 days with phenobarbital (80 mg/Kg of body weight, semichronic treatment) in order to induc