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1-Methyl-4-[5(3)-methyl-3(5)-pyrazolyl]quinolinium iodide. An analog of the hypoglycemic pyrazolylpyridinium salts

✍ Scribed by Williams, Richard P.; Bauer, Victor J.; Safir, Sidney R.


Book ID
126177261
Publisher
American Chemical Society
Year
1969
Tongue
English
Weight
255 KB
Volume
12
Category
Article
ISSN
0022-2623

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✍ Wieslaw Gessner; Arnold Brossi; Rong-Sen Shen; Richard R. Fritz; Creed W. Abell 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 German ⚖ 383 KB

## Abstract Monoamine oxidase B metabolizes 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP; **1**) first to 1‐methyl‐4‐phenyl‐2,3‐dihydropyridinium salt (MPDP^+^; **5**), and then to 1‐methyl‐4‐phenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5‐methyl analog **6** wa