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1-Methyl-4-(2′-methylphenyl)-1,2,3,6-tetrahydropyridine (2′-CH3-MPTP) is a more potent dopaminergic neurotoxin than MPTP in mice

✍ Scribed by Stephen K. Youngster; Roger C. Duvoisin; Arthur Hess; Patricia K. Sonsalla; M.Victoria Kindt; Richard E. Heikkila


Book ID
115879808
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
678 KB
Volume
122
Category
Article
ISSN
0014-2999

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP