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1-(Carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists

✍ Scribed by Weinstock, Joseph; Keenan, Richard M.; Samanen, James; Hempel, Judith; Finkelstein, Joseph A.; Franz, Robert G.; Gaitanopoulos, Dimitri E.; Girard, Gerald R.; Gleason, John G.

Book ID: 127128606
Publisher: American Chemical Society
Year: 1991
Tongue: English
Weight: 420 KB
Volume: 34
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00108a043

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## Abstract [α‐^11^C]Benzoyl chloride was synthesized and purified by normal phase HPLC. [^11^C]MK‐996 ([^11^C]__N__‐[[4′[(2‐ethyl‐5,7‐dimethyl‐3H‐imidazo [4,5‐b]pyridin‐3‐yl)methyl][1,1′‐biphenyl]‐2‐yl]sulfonyl]‐benzamide), a potent and selective ligand for the AT~1~ receptor, was prepared by __N_