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1-Bromo-4,4,4-trifluoro-3-(trifluoromethyl)but-2-ene: synthesis and electrophilic reactivity

✍ Scribed by Valérie Martin; Huguette Molines; Claude Wakselman


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
345 KB
Volume
71
Category
Article
ISSN
0022-1139

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Reaction of Ethyl 4,4,4-Trifluoroacetoacetate Enolate with 3-Bromo-1,1, 1-trifluoroacetone: Synthesis of 2,4-Bis(trifluoromethyl)furan. -The title reaction follows competing courses such as C-acylation, O-alkylation and di-O-alkylation which result in the formation of two major products (III) and (I