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1-Aryl-4,6-diamino-1,2-dihydrotriazine as Antimalarial Agent: A New Synthetic Route.

✍ Scribed by M. Kidwai; P. Mothsra; R. Mohan; S. Biswas


Book ID
101973662
Publisher
John Wiley and Sons
Year
2005
Weight
16 KB
Volume
36
Category
Article
ISSN
0931-7597

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A new, three-stage synthesis of 1,3,5-triamino-2,4,6-trinitrobenzene (TATB) has been developed which avoids the use of halogenated precursors or reagents. The starting material, 1,3,5trihydroxy-benzene, is converted via the sequence nitrationalkylation-amination to TATB in an overall yield of 87%. T