## Abstract We evaluated whether patients with earlyβonset Parkinson's disease (EOPD) have a different clinical profile and pharmacological response than those with lateβonset disease (LOPD). We performed a retrospective analysis and an acute pharmacological challenge with LβDopa in 34 EOPD (age at
1-30-04 Clinical correlates of early and late onset Parkinson's disease patients
β Scribed by L.A.F. Andrade; S.M.C. Azevedo-Silva; H.B. Ferraz; P.M.C. Aguiar; O.G.P. Barsottini; V. Borges
- Book ID
- 119469096
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 167 KB
- Volume
- 150
- Category
- Article
- ISSN
- 0022-510X
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## Abstract Homozygous or compound heterozygous mutations in the __PINK1__ gene represent the second most frequent cause of autosomal recessive parkinsonism after __Parkin__. The phenotype differs from idiopathic Parkinson's disease for earlier onset, slower disease progression, and better response