054 EXTRACELLULAR SULFATASES SUPPORT CARTILAGE HOMEOSTASIS BY REGULATING BMP AND FGF SIGNALING PATHWAYS

Extracellular-signal regulated kinase si

Extracellular-signal regulated kinase signaling pathway mediates downregulation of type I procollagen gene expression by FGF-2, PDGF-BB, and okadaic acid in osteoblastic cells

✍ Lala R. Chaudhary; Louis V. Avioli 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 1 views

Although basic fibroblast growth factor (FGF-2) had been shown to inhibit type I collagen gene expression in osteoblast, its inhibitory mechanism is unknown. In the present study, we investigated the underlying mechanisms by which growth factors downregulate type I collagen gene expression. Treatmen