Heterozygous R1101K mutation of the DCTN
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Christoph MΓΌnch; Angela Rosenbohm; Anne-Dorte Sperfeld; Ingo Uttner; Sven Reske;
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Article
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2005
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John Wiley and Sons
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English
β 561 KB
## Abstract A heterozygous R1101K mutation of the p150 subunit of dynactin (DCTN1) is reported in a family with amyotrophic lateral sclerosis (ALS) and coβoccurrence of frontotemporal dementia (FTD). Two members of our kindred were affected with motor neuron disease and two with dementia in an auto