To study the expression of the alpha1-alpha6 chains of type IV collagen in the dermoepidermal junction (DEJ) during human foetal skin development, human foetal (10 and 20 weeks of gestation) and adult skin was immunostained with specific monoclonal antibodies to the alpha1-alpha6 chains of type IV c
040 Preferential expression of α2 and α4 chains of type IV collagen in the developing human fetal skin
✍ Scribed by Tanaka, N.; Tajima, S.; Ishibashi, A.; Sado, Y.; Ninomiya, Y.
- Book ID
- 119561507
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 130 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0923-1811
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The basement membrane type IV collagen is a family composed of six genetically distinct but structurally similar polypeptide chains, ␣1-␣6. The ␣1(IV) and ␣2(IV) chains are ubiquitous components of all BMs whereas the other four have a restricted tissue distribution. In the present study, we have an
Type IV collagen trimer is a major component of basement membranes (BMs). It is composed of polypeptides named a1(IV)-a6(IV) chains. Chains a1,2(IV) are widely expressed in BMs while a3(IV)-a6(IV) are more restricted in human tissues. We have now studied by immunohistochemical means the distribution