029 Evaluation of binding characteristics of bile acid sequestrants using ox bile
✍ Scribed by S. Müllner; E. Granzer; R. Hofmann; B. Karbe-Thönges; K. Saar
- Book ID
- 112293007
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 138 KB
- Volume
- 343
- Category
- Article
- ISSN
- 1618-2650
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Cholestyramine is a bile acid sequestrant, like colestipol and colesevelam. These molecules are positively charged non-digestible resins that bind to bile acids in the intestine to form an insoluble complex, which is excreted in the feces. They are used mainly for the treatment of primary hyperchole
DMP 504 is a novel bile acid sequestrant under development for the treatment of primary hypercholesterolemia. The resin is a soft-textured "hydrogel" that is synthesized from 1,10-dibromodecane and 1,6-diaminohexane. The equilibrium binding parameters for DMP 504 have been determined and compared to