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0207 Paraoxonase 1 (PON1) gene polymorphisms (M55L and Q192R) and osteonecrosis of the femoral head with and without cerebral white matter lesions

Book ID
119466756
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
249 KB
Volume
238
Category
Article
ISSN
0022-510X

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Paraoxonase 1 gene polymorphisms in pati
Paraoxonase 1 gene polymorphisms in patients with osteonecrosis of the femoral head with and without cerebral white matter lesions
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## Abstract Cerebral white matter lesions (WML) are present in more than 50% of patients with osteonecrosis of the femoral head (ONFH). Paraoxonase 1 __(PON1)__ gene product is a detoxifying and pesticide metabolizing enzyme. Genetic variants of the __PON1__ gene have been found to influence the oc

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## Abstract Paraoxonase 1 (PON 1) is a high‐density lipoprotein (HDL)‐associated enzyme with antioxidant function protecting low‐density lipoprotein (LDL) from oxidation. PON 1 has two amino acid polymorphisms in coding region; L/M 55 and Q/R 192. These polymorphisms modulate paraoxonase activity o