Allelic losses of tumor suppressor genes (TSGs), or the chromosomal regions harboring them, in tumor DNA may become useful postoperative prognostic indicators. To examine whether specific allelic losses might correlate with postoperative survival in a 5-year prospective follow-up, we tested tumors f
0-65. Allelic imbalance at chromosome 17p13.3(YNZ22) and poor prognosis in breast cancer
β Scribed by A.M. Thompson; M. Clay; D. Crichton; R. Elton; U. Chetty; C.M. Steel
- Book ID
- 114317071
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 153 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-9776
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Loss of heterozygosity (LOH) or allelic imbalance, the latter term referring to both loss and gain of an allele, on the long arm of chromosome 16 has been repeatedly found in cancers of, e.g., the breast and prostate. This indicates the presence of one or more tumor suppressor genes on
The development of human breast cancer is characterized by a variety of genetic alterations, and cytogenetic analyses have documented the consistent involvement of both arms of chromosome I. In the present study, molecular markers detecting restriction fragment length polymorphisms were used in pair